In Vitro Effects of Annona Senegalensis Root Bark, Musa Sapientum L and Malus Pumila Peel Extracts On Xanthine Oxidase

Background: Xanthine Oxidase activity may increase plasma urates, superoxide radicals and hydrogen peroxide leading to gout, arthritis cancer. Allopurinol, a known inhibitor, is noted have various adverse effects. Many laboratories are in research projects find alternative inhibitors of XO including plant sources. Plants contain therapeutically effective agents. A. senegalensis, M. sapientum L Pumila reported phytochemicals with antioxidant, anti-inflammatory enzyme inhibitory activities. Methods: Aqueous extracts Root bark peels pumila were assayed for their effects on oxidase vitro Results: All aqueous exhibited the presence flavonoids. senegalensis root M investigated activity. bark, peel inhibited by 83%, 90% 61% respectively as which significantly different (p <0.05) from that positive control, allopurinol (65%) Conclusions: The results obtained this study suggest flavonoids found could be potential inhibitors.